Transplantation‐associated thrombotic microangiopathy isolated to a congenital anomaly of the lung. (24th November 2016)

• Record Type: Journal Article
• Authors: Kummen, Rebecca T.; Cuvelier, Geoffrey D. E.; Stefanovici, Camelia; Perry, Anamarija M.; Higgins, Rick; Yanofsky, Rochelle; Lum Min, Suyin A.; Wall, Donna A.
• Is Part Of: Pediatric transplantation. Volume 21:Number 1(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-11-24
• Subjects: allogeneic stem cell transplantation -- anemia -- child -- graft‐vs‐host disease -- lung diseases -- pediatric hematopoietic stem cell; Transplantation of organs, tissues, etc. in children -- Periodicals; 617.95408305
• DOI: 10.1111/petr.12824
• Languages: English
• ISSNs: 1397-3142

Abstract

Abstract: TA‐TMA is a post‐hematopoietic stem cell transplant complication with clinical features of hemolytic anemia and thrombocytopenia. A 26‐month‐old child who had had an allogeneic transplant for treatment of DBA developed severe TA‐TMA with heavy red blood cell and platelet transfusion dependence. Incidentally, he was found to have a lung sequestration. TA‐TMA resolved and transfusion dependence resolved after resection of the sequestration. The finding suggests the malformation vasculature was selectively vulnerable to the trigger of TA‐TMA—raising perhaps a clue to basic pathophysiology of TA‐TMA and/or vascular malformations.