Transplantation‐associated thrombotic microangiopathy isolated to a congenital anomaly of the lung. (24th November 2016) - Kummen, Rebecca T.
Abstract: TA‐TMA is a post‐hematopoietic stem cell transplant complication with clinical features of hemolytic anemia and thrombocytopenia. A 26‐month‐old child who had had an allogeneic transplant for treatment of DBA developed severe TA‐TMA with heavy red blood cell and platelet transfusion dependence. Incidentally, he was found to have a lung sequestration. TA‐TMA resolved and transfusion dependence resolved after resection of the sequestration. The finding suggests the malformation vasculature was selectively vulnerable to the trigger of TA‐TMA—raising perhaps a clue to basic pathophysiology of TA‐TMA and/or vascular malformations.