Carboxin and its major metabolites residues in peanuts: Levels, dietary intake and chronic intake risk assessment. (1st March 2019)

• Record Type: Journal Article
• Authors: Wei, Dongmei; Wu, Xiaohu; Ji, Mingshan; Xu, Jun; Dong, Fengshou; Liu, Xingang; Zheng, Yongquan
• Is Part Of: Food chemistry. Volume 275(2019)
• Page Start: 169
• Page End: 175
• Publication Date: 2019-03-01
• Subjects: LC-MS/MS Liquid chromatography-tandem mass spectrometry -- QuEChERS Quick, Easy, Cheap, Effective, Rugged, and Safe -- ADI acceptable daily intake -- MRL maximum residue level -- MeCN acetonitrile -- PSA Primary secondary amine; Carboxin -- Metabolites -- Peanut -- QuEChERS -- Residues -- Dietary risk assessment; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2018.09.087
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: A QuEChERS method was modified of carboxin and its metabolites in peanuts. Supervised field trials were conducted of carboxin in peanuts. The total carboxin in peanut samples from fields and markets were measured. The carboxin-exposure risk by eating peanuts was evaluated via a probabilistic model. Abstract: We developed an ultra-performance liquid chromatography-tandem mass spectral method to determine the fungicide carboxin and its metabolites, oxycarboxin and carboxin sulfoxide in peanut samples. The method was used to detect the concentration of the analytes in the samples from fields and markets. The total residue quantities in peanut kernels were used to evaluate the chronic dietary risk of total carboxin upon peanut consumption. The estimated dietary intake of carboxin from peanuts whose seeds had been treated with carboxin at the recommended dose was between 0.020% and 0.344% of acceptable daily intake and the risk was found to be negligible. The chronic dietary risk assessment from markets and commercial field samples for various groups of humans indicated that the group with the greatest degree of exposure was 45 to 75-year-old women who lived in rural areas. However, their acceptable daily intake percentage was 0.006%, meaning that their health risk was extremely small.