A single spike deteriorates synaptic conductance estimation. (November 2017)

• Record Type: Journal Article
• Authors: Kobayashi, Ryota; Nishimaru, Hiroshi; Nishijo, Hisao; Lansky, Petr
• Is Part Of: Bio systems. Volume 161(2017)
• Page Start: 41
• Page End: 45
• Publication Date: 2017-11
• Subjects: Synaptic conductance estimation -- Single neuron models -- Ornstein–Uhlenbeck process; Biological systems -- Periodicals; Biology -- Periodicals; Biology -- Periodicals; Evolution -- Periodicals; Biologie -- Périodiques; Évolution -- Périodiques; 570
• DOI: 10.1016/j.biosystems.2017.07.007
• Languages: English
• ISSNs: 0303-2647

Abstract

Abstract: We investigated the estimation accuracy of synaptic conductances by analyzing simulated voltage traces generated by a Hodgkin–Huxley type model. We show that even a single spike substantially deteriorates the estimation. We also demonstrate that two approaches, namely, negative current injection and spike removal, can ameliorate this deterioration.