A single spike deteriorates synaptic conductance estimation. (November 2017) - Kobayashi, Ryota
Abstract: We investigated the estimation accuracy of synaptic conductances by analyzing simulated voltage traces generated by a Hodgkin–Huxley type model. We show that even a single spike substantially deteriorates the estimation. We also demonstrate that two approaches, namely, negative current injection and spike removal, can ameliorate this deterioration.