Biomarkers for Ilex pubescens under anti-platelet activity-oriented isolation. (August 2015)

• Record Type: Journal Article
• Authors: Lin, Li-Ping; Li, Ying; Zhang, Ji-Chao; Lu, Ye
• Is Part Of: Biochemical systematics and ecology. Volume 61(2015)
• Page Start: 8
• Page End: 11
• Publication Date: 2015-08
• Subjects: Ilex pubescens -- Aquifoliaceae -- Triterpenoid -- Anti-platelet activity-oriented isolation -- Chemotaxonomy; Chemotaxonomy -- Periodicals; Biochemical variation -- Periodicals; Ecology -- Periodicals; Biochemistry -- Periodicals; Ecology -- Periodicals; Chimiotaxinomie -- Périodiques; Variation biochimique -- Périodiques; Écologie -- Périodiques; 578.012
• DOI: 10.1016/j.bse.2015.05.006
• Languages: English
• ISSNs: 0305-1978

Abstract

Abstract: In the present study, eleven ursane triterpenoids (1—11 ), seven oleanane triterpenoids (12—18 ), one lupine sapogenin (19 ) as well as two sterols (20 and21 ) were obtained from Ilex pubescens under the anti-platelet activity-oriented isolation. Among them, compounds2 and4 were isolated from I. pubescens for the first time, while the isolation of the compounds12, 15, 16 and17 was a new finding in the Aquifoliaceae family. Our present study exhibited the taxonomic relationships (similarities and differences) between I. pubescens and some other species of genus Ilex . The result also suggested that triterpenoids are the anti-platelet components which may be fingerprints and serve as biomarkers for seeking alternative sources for I. pubescens . Highlights: We studied the chemical constituents of the roots of Ilex pubescens Hook. et Arn. and obtained twenty-one compounds which were elucidated by spectroscopic methods. Compounds12 and15 ─17 were isolated from Aquifoliaceae family for the first time, while compounds2 and4 were obtained firstly from I. pubescens . This study exhibited triterpenoids may serve as biomarkers for seeking alternative sources for I. pubescens .