Biomarkers for Ilex pubescens under anti-platelet activity-oriented isolation. (August 2015) - Lin, Li-Ping
Abstract: In the present study, eleven ursane triterpenoids (1—11 ), seven oleanane triterpenoids (12—18 ), one lupine sapogenin (19 ) as well as two sterols (20 and21 ) were obtained from Ilex pubescens under the anti-platelet activity-oriented isolation. Among them, compounds2 and4 were isolated from I. pubescens for the first time, while the isolation of the compounds12, 15, 16 and17 was a new finding in the Aquifoliaceae family. Our present study exhibited the taxonomic relationships (similarities and differences) between I. pubescens and some other species of genus Ilex . The result also suggested that triterpenoids are the anti-platelet components which may be fingerprints and serve as biomarkers for seeking alternative sources for I. pubescens . Highlights: We studied the chemical constituents of the roots of Ilex pubescens Hook. et Arn. and obtained twenty-one compounds which were elucidated by spectroscopic methods. Compounds12 and15 ─17 were isolated from Aquifoliaceae family for the first time, while compounds2 and4 were obtained firstly from I. pubescens . This study exhibited triterpenoids may serve as biomarkers for seeking alternative sources for I. pubescens .