Genome-derived cytosolic DNA contributes to type I interferon expression and immunogenicity of B-cell lymphoma cells. Issue 2 (December 2015)

• Record Type: Journal Article
• Authors: Shen, Yu J.; Ho, Samantha S.W.; Tan, Nikki Y.; Koo, Christine Xing'Er; Khatoo, Muznah; Cheung, Florence S.G.; Gasser, Stephan
• Is Part Of: Cytokine. Volume 76:Issue 2(2015)
• Page Start: 581
• Page End: 582
• Publication Date: 2015-12
• Subjects: Type I interferon -- Cancer -- Innate immunity -- Non-B DNA motifs -- DNA sensors; Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.05.024
• Languages: English
• ISSNs: 1043-4666

Abstract

Highlights: Genome-derived ssDNA, dsDNA and DNA:RNA hybrids are present in the cytosol of tumor cells. Cytosolic DNA can potentially form non-B DNA structures. Cytosolic DNA contributes to type I interferon-dependent immune rejection of B-cell lymphoma. Abstract: We recently provided evidence that genome-derived DNA is present in the cytosol of many tumor cells. Genomic loci that give rise to cytosolic DNA can potentially form non-B DNA structures including triple-stranded RNA:DNA structures (R-loops). The RNA:DNA-specific endonuclease RNaseh1 reduced the levels of cytosolic DNA and type I interferon-dependent rejection of B-cell lymphoma suggesting that cytosolic DNA may contribute to immune surveillance of B-cell lymphoma.