Genome-derived cytosolic DNA contributes to type I interferon expression and immunogenicity of B-cell lymphoma cells. Issue 2 (December 2015) - Shen, Yu J.
Highlights: Genome-derived ssDNA, dsDNA and DNA:RNA hybrids are present in the cytosol of tumor cells. Cytosolic DNA can potentially form non-B DNA structures. Cytosolic DNA contributes to type I interferon-dependent immune rejection of B-cell lymphoma. Abstract: We recently provided evidence that genome-derived DNA is present in the cytosol of many tumor cells. Genomic loci that give rise to cytosolic DNA can potentially form non-B DNA structures including triple-stranded RNA:DNA structures (R-loops). The RNA:DNA-specific endonuclease RNaseh1 reduced the levels of cytosolic DNA and type I interferon-dependent rejection of B-cell lymphoma suggesting that cytosolic DNA may contribute to immune surveillance of B-cell lymphoma.