A new and efficient synthesis of pyrazole-fused isocoumarins on the solid surface of magnetically separable Fe3O4@SiO2-SO3H nanoparticles. Issue 19 (11th May 2016)

• Record Type: Journal Article
• Authors: Mukherjee, Sayan; Kundu, Ashis; Pramanik, Animesh
• Is Part Of: Tetrahedron letters. Volume 57:Issue 19(2016)
• Page Start: 2103
• Page End: 2108
• Publication Date: 2016-05-11
• Subjects: Ninhydrin -- Arylhydrazones -- Pyrazole-fused isocoumarins -- Magnetic nanoparticles -- Green method; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2016.04.002
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: New and efficient synthesis of GABA receptor binding pyrazole-fused isocoumarins. Use of magnetically separable Fe3 O4 @SiO2 -SO3 H nanoparticles as solid acid support. Solvent-free and chromatography-free synthesis. Easily available starting materials, good yield of products, and high atom-economy. The present method is economical, green, and sustainable. Abstract: A new and efficient procedure has been developed for the synthesis of a series of pyrazole-fused isocoumarins from easily available ninhydrin and arylhydrazones. In this synthesis the condensations of ninhydrin and arylhydrazones are carried out under solvent free conditions employing magnetically separable Fe3 O4 @SiO2 -SO3 H nanoparticles as solid acid support. Some members of pyrazole-fused isocoumarins are known to bind to a GABA receptor.