A new and efficient synthesis of pyrazole-fused isocoumarins on the solid surface of magnetically separable Fe3O4@SiO2-SO3H nanoparticles. Issue 19 (11th May 2016) - Mukherjee, Sayan
Graphical abstract: Highlights: New and efficient synthesis of GABA receptor binding pyrazole-fused isocoumarins. Use of magnetically separable Fe3 O4 @SiO2 -SO3 H nanoparticles as solid acid support. Solvent-free and chromatography-free synthesis. Easily available starting materials, good yield of products, and high atom-economy. The present method is economical, green, and sustainable. Abstract: A new and efficient procedure has been developed for the synthesis of a series of pyrazole-fused isocoumarins from easily available ninhydrin and arylhydrazones. In this synthesis the condensations of ninhydrin and arylhydrazones are carried out under solvent free conditions employing magnetically separable Fe3 O4 @SiO2 -SO3 H nanoparticles as solid acid support. Some members of pyrazole-fused isocoumarins are known to bind to a GABA receptor.