Breathable tissue engineering scaffolds: An efficient design-optimization by additive manufacturing. (2018)

• Record Type: Journal Article
• Authors: Touri, Maria; Moztarzadeh, Fathollah; Osman, Noor Azuan Abu; Dehghan, Mohammad Mehdi; Mozafari, Masoud
• Is Part Of: Materials today. Volume 5:Number 7(2018)Part 3
• Page Start: 15813
• Page End: 15820
• Publication Date: 2018
• Subjects: Oxygen-producing -- Robocasting -- 3-D scaffolds -- Bone tissue engineering; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2018.05.079
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: Supplying sufficient oxygen to engineered tissue, has been a major challenge for overcoming the effect of hypoxia. Using of oxygen producing scaffolds has opened a window to prevent ischemia-related cell necrosis. In this study, biphasic calcium phosphate (BCP) porous structures consisting of a 3-D tetragonal mesh of interpenetrating ceramic rods were fabricated by robocasting technique. Calcium peroxide (CPO, 3 wt%), was encapsulated within the polycaprolactone (PCL) coating layer through a dip-coating method. The presence of CPO particles in coated scaffolds played the role of a driving force for formation of apatite in SBF test then compared to uncoated scaffold, the coated scaffold presented a better ability of precipitation. The sustained oxygen release ensured the effectiveness of the coating-scaffold design as an oxygen delivery system. The coated scaffolds with 3% CPO, could also improve osteoblasts viability and proliferation. These findings show that the prepared scaffolds can be a great candidate in bone tissue engineering with promoting of bone ingrowth.