Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides. Issue 35 (4th September 2018)

• Record Type: Journal Article
• Authors: Bandyopadhyay, Debashruti; Thirupathi, Annaram; Dhage, Nagsen Munjaji; Mohanta, Nirmala; Peruncheralathan, S.
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 35(2018)
• Page Start: 6405
• Page End: 6409
• Publication Date: 2018-09-04
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob01712c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A nickel catalyzed C–H bond functionalization reaction has been used for the first time to study an intramolecular site-selective C–S bond formation of arenes. Abstract : A catalytic site selective intramolecular C–S bond forming reaction is demonstrated for the first time. The C–H bond functionalization of α-aryl-thioacetanilides was efficiently catalyzed by 2 mol% NiBr2, resulting in valuable 2-aminobenzo[ b ]thiophenes in moderate to good yields. Furthermore, the selective sp 2 C–H bond functionalization over sp 3 is exemplified.