Nickel catalyzed site selective C–H functionalization of α-aryl-thioamides. Issue 35 (4th September 2018) - Bandyopadhyay, Debashruti
Abstract : A nickel catalyzed C–H bond functionalization reaction has been used for the first time to study an intramolecular site-selective C–S bond formation of arenes. Abstract : A catalytic site selective intramolecular C–S bond forming reaction is demonstrated for the first time. The C–H bond functionalization of α-aryl-thioacetanilides was efficiently catalyzed by 2 mol% NiBr2, resulting in valuable 2-aminobenzo[ b ]thiophenes in moderate to good yields. Furthermore, the selective sp 2 C–H bond functionalization over sp 3 is exemplified.