ADHD Symptom Rebound and Emotional Lability With Lisdexamfetamine Dimesylate in Children Aged 6 to 12 Years. (January 2017)

• Record Type: Journal Article
• Authors: López, Frank A.; Childress, Ann; Adeyi, Ben; Dirks, Bryan; Babcock, Thomas; Scheckner, Brian; Lasser, Robert A.; Shepski, John; Arnold, Valerie
• Is Part Of: Journal of attention disorders. Volume 21:Number 1(2017)
• Page Start: 52
• Page End: 61
• Publication Date: 2017-01
• Subjects: symptom rebound -- ADHD -- emotional lability -- lisdexamfetamine dimesylate; Attention-deficit hyperactivity disorder -- Periodicals; Attention -- Periodicals; 616.8589
• DOI: 10.1177/1087054712474685
• Languages: English
• ISSNs: 1087-0547

Abstract

Objective: To describe symptom rebound in children with ADHD treated with lisdexamfetamine dimesylate (LDX) or placebo.Method: During a 4-week, randomized, double-blind, placebo-controlled trial of LDX, parents/caregivers completed the Conners' Parent Rating Scale–Revised: Short Form symptom rating scale throughout the day. Response, rebound, and emotional lability (EL) were assessed post hoc based on predefined criteria.Results: Most participants given LDX ( n = 207) were responders throughout the day (50.7%-55.6%) versus placebo ( n = 72; 11.1%-22.2%). A total of seven (3.4%) LDX participants showed rebound in the afternoon and/or evening versus seven (9.7%) with placebo. In both groups, most incidences of rebound occurred in the evening. EL (mean) was higher in LDX rebounders and nonresponders (range = 4.2-9.0) versus LDX responders (range = 1.3-1.6) and versus placebo rebounders (range = 0.7-1.9).Conclusion: ADHD symptom rebound occurred in few participants (3.3%) given LDX (accompanied by clinically significant EL). Overall, more participants given LDX versus placebo responded throughout the day.