A camphor based 1, 3-diamine Ru(ii) terpyridine complex: synthesis, characterization, kinetic investigation and DNA binding. (5th February 2018)

• Record Type: Journal Article
• Authors: Milutinović, Milan M.; Bugarčić, Živadin D.; Wilhelm, René
• Is Part Of: New journal of chemistry. Volume 42:Number 10(2018)
• Page Start: 7607
• Page End: 7611
• Publication Date: 2018-02-05
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj04674j
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A chiral ancillary ligand that has more steric bulk results in an increased reactivity of a ruthenium complex with biomolecules. Abstract : The synthesis and reactivity of a new ruthenium(ii ) terpyridine complex with a bidentate enantiopure camphor based diamine ligand is described. Reactivity measurements of the Ru(ii ) complex showed a high affinity towards guanosine-5′-monophosphate as a model for DNA bases. Furthermore, the Ru(ii ) complex was found to interact with CT-DNA. This suggests the high potential of the newly synthesized ruthenium complex as an antitumor agent.