A camphor based 1, 3-diamine Ru(ii) terpyridine complex: synthesis, characterization, kinetic investigation and DNA binding. (5th February 2018) - Milutinović, Milan M.
Abstract : A chiral ancillary ligand that has more steric bulk results in an increased reactivity of a ruthenium complex with biomolecules. Abstract : The synthesis and reactivity of a new ruthenium(ii ) terpyridine complex with a bidentate enantiopure camphor based diamine ligand is described. Reactivity measurements of the Ru(ii ) complex showed a high affinity towards guanosine-5′-monophosphate as a model for DNA bases. Furthermore, the Ru(ii ) complex was found to interact with CT-DNA. This suggests the high potential of the newly synthesized ruthenium complex as an antitumor agent.