2, 3-Diaroyl benzofurans from arynes: sequential synthesis of 2-aroyl benzofurans followed by benzoylation. Issue 17 (11th April 2018)

• Record Type: Journal Article
• Authors: Neog, Kashmiri; Das, Babulal; Gogoi, Pranjal
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 17(2018)
• Page Start: 3138
• Page End: 3150
• Publication Date: 2018-04-11
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c8ob00631h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been described. The synthesized 2-aroyl benzofurans were further benzoylated for the synthesis of 2, 3-diaroyl benzofurans. Abstract : A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been developed. This reaction proceeds via C–O and C–C bond cleavage as well as C–O and C–C bond formation in a single reaction vessel. The methodology provides good yields of 2-aroyl benzofurans and tolerates a variety of functional groups. The synthesized 2-aroyl benzofurans were further benzoylated at 3-positions and one of the synthesized 2, 3-diaroyl benzofuran structures was confirmed unambiguously by X-ray crystallography.