2, 3-Diaroyl benzofurans from arynes: sequential synthesis of 2-aroyl benzofurans followed by benzoylation. Issue 17 (11th April 2018) - Neog, Kashmiri
Abstract : A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been described. The synthesized 2-aroyl benzofurans were further benzoylated for the synthesis of 2, 3-diaroyl benzofurans. Abstract : A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been developed. This reaction proceeds via C–O and C–C bond cleavage as well as C–O and C–C bond formation in a single reaction vessel. The methodology provides good yields of 2-aroyl benzofurans and tolerates a variety of functional groups. The synthesized 2-aroyl benzofurans were further benzoylated at 3-positions and one of the synthesized 2, 3-diaroyl benzofuran structures was confirmed unambiguously by X-ray crystallography.