Convenient synthesis of α, α-(bisallyl and bispropargyl)-substituted amines via aza-Barbier-type reaction. Issue 19 (6th May 2015)

• Record Type: Journal Article
• Authors: Guo, Tao; Liu, Ying-Chao; Li, Bo; Liu, Hong-Min
• Is Part Of: Tetrahedron letters. Volume 56:Issue 19(2015)
• Page Start: 2469
• Page End: 2471
• Publication Date: 2015-05-06
• Subjects: Allylation -- Propargylation -- aza-Barbier reaction -- Sulfonyl imidate; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2015.03.103
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: A convenient and efficient approach for the synthesis of α, α-(bisallyl and bispropargyl)-substituted amines has been developed in good yields via Zn-promoted aza -Barbier-type reactions of N -sulfonyl imidates with various allyl and propargyl reagents. The synthetic utility of this approach was demonstrated by the rapid construction of pyrrolidine derivatives.