Convenient synthesis of α, α-(bisallyl and bispropargyl)-substituted amines via aza-Barbier-type reaction. Issue 19 (6th May 2015) - Guo, Tao
Graphical abstract: Abstract: A convenient and efficient approach for the synthesis of α, α-(bisallyl and bispropargyl)-substituted amines has been developed in good yields via Zn-promoted aza -Barbier-type reactions of N -sulfonyl imidates with various allyl and propargyl reagents. The synthetic utility of this approach was demonstrated by the rapid construction of pyrrolidine derivatives.