HMENA11a, a hMENA isoform sending survival signals. (3rd March 2016)

• Record Type: Journal Article
• Authors: Trono, Paola; Di Modugno, Francesca; Nisticò, Paola
• Is Part Of: Molecular & cellular oncology. Volume 3:Number 2(2016)
• Publication Date: 2016-03-03
• Subjects: Breast cancer -- HER3 -- oncogenic signaling -- PI3K -- therapy resistance; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2015.1083648
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Human MENA 11a (hMENA 11a ), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA 11a as a marker of HER3 activation and resistance to phosphatidylinositol-3-kinase inhibition therapies.