HMENA11a, a hMENA isoform sending survival signals. (3rd March 2016) - Trono, Paola
ABSTRACT: Human MENA 11a (hMENA 11a ), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA 11a as a marker of HER3 activation and resistance to phosphatidylinositol-3-kinase inhibition therapies.