Automated radiosynthesis of [18F]ciprofloxacin. (May 2015)

• Record Type: Journal Article
• Authors: Stanek, Johann; Mairinger, Severin; Wanek, Thomas; Kuntner, Claudia; Müller, Markus; Langer, Oliver
• Is Part Of: Applied radiation and isotopes. Volume 99(2015:May)
• Page Start: 133
• Page End: 137
• Publication Date: 2015-05
• Subjects: [18F]ciprofloxacin -- Automated synthesis -- TRACERlabTM FXFDG -- Radiochemical yield -- Reactor type -- 18F/19F exchange; Radiology -- Periodicals; Radiation -- Industrial applications -- Periodicals; Nuclear chemistry -- Periodicals; Internet resource; Periodical; 660.298
• DOI: 10.1016/j.apradiso.2015.02.024
• Languages: English
• ISSNs: 0969-8043

Abstract

Abstract: We transferred the previously published manual synthesis of [ 18 F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab TM FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass reactor a considerable improvement in RCY was observed. [ 18 F]Ciprofloxacin was obtained in a RCY of 2.7±1.4% ( n =23) with a specific activity at EOS of 1.4±0.5 GBq/µmol in a synthesis time of 160 min. Graphical abstract: Highlights: Automated synthesis of [ 18 F]ciprofloxacin in a TRACERlab TM FXFDG (GE Healthcare) synthesis module was developed. Dependence of radiochemical yield on reactor type was observed. 3-mL V-shaped borosilicate glass reactor gave higher radiochemical yield as compared with standard 15-mL glassy carbon reactor. V-shaped borosilicate glass reactor might also give higher radiochemical yield for other [ 18 F]radiotracers than [ 18 F]ciprofloxacin.