Automated radiosynthesis of [18F]ciprofloxacin. (May 2015) - Stanek, Johann
Abstract: We transferred the previously published manual synthesis of [ 18 F]ciprofloxacin (decay-corrected RCY: 5.5±1.0%) to an automated synthesis module (TRACERlab TM FXFDG, GE Healthcare) and observed a strong decrease in RCY (0.4±0.4%). When replacing the standard 15-mL glassy carbon reactor of the synthesis module with a 3-mL V-shaped borosilicate glass reactor a considerable improvement in RCY was observed. [ 18 F]Ciprofloxacin was obtained in a RCY of 2.7±1.4% ( n =23) with a specific activity at EOS of 1.4±0.5 GBq/µmol in a synthesis time of 160 min. Graphical abstract: Highlights: Automated synthesis of [ 18 F]ciprofloxacin in a TRACERlab TM FXFDG (GE Healthcare) synthesis module was developed. Dependence of radiochemical yield on reactor type was observed. 3-mL V-shaped borosilicate glass reactor gave higher radiochemical yield as compared with standard 15-mL glassy carbon reactor. V-shaped borosilicate glass reactor might also give higher radiochemical yield for other [ 18 F]radiotracers than [ 18 F]ciprofloxacin.