Silver-mediated direct C–H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents. Issue 26 (20th February 2018)

• Record Type: Journal Article
• Authors: Zhang, Huaxing; Chen, Xingyu; Lan, Jingbo; Liu, Yanhong; Zhou, Fulin; Wu, Di; You, Jingsong
• Is Part Of: Chemical communications. Volume 54:Issue 26(2018)
• Page Start: 3219
• Page End: 3222
• Publication Date: 2018-02-20
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc00238j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A highly efficient Ag(i )-mediated direct C–H amination of BODIPYs is accomplished. BODIPYs3q and4b exhibit specific ER-targeting capacities. Abstract : A highly efficient direct C–H amination of BODIPYs has been accomplished through the Ag(i )-mediated nucleophilic addition of an amino radical to BODIPY at the C3- and/or C5-position and deprotonation processes under mild conditions. This protocol greatly streamlines the access to a variety of 3-aminated and 3, 5-diaminated BODIPYs. The resulting BODIPYs with morpholine groups (3q and4b ) exhibit specific endoplasmic reticulum (ER)-localization capacities and negligible cytotoxicities, which would be potential ER-targeting reagents.