Silver-mediated direct C–H amination of BODIPYs for screening endoplasmic reticulum-targeting reagents. Issue 26 (20th February 2018) - Zhang, Huaxing
Abstract : A highly efficient Ag(i )-mediated direct C–H amination of BODIPYs is accomplished. BODIPYs3q and4b exhibit specific ER-targeting capacities. Abstract : A highly efficient direct C–H amination of BODIPYs has been accomplished through the Ag(i )-mediated nucleophilic addition of an amino radical to BODIPY at the C3- and/or C5-position and deprotonation processes under mild conditions. This protocol greatly streamlines the access to a variety of 3-aminated and 3, 5-diaminated BODIPYs. The resulting BODIPYs with morpholine groups (3q and4b ) exhibit specific endoplasmic reticulum (ER)-localization capacities and negligible cytotoxicities, which would be potential ER-targeting reagents.