Naringin Protects Pancreatic β‐Cells Against Oxidative Stress‐Induced Apoptosis by Inhibiting Both Intrinsic and Extrinsic Pathways in Insulin‐Deficient Diabetic Mice. Issue 5 (5th February 2018)

• Record Type: Journal Article
• Authors: Lim, Ye Jin; Kim, Jung Ho; Pan, Jeong Hoon; Kim, Jae Kyeom; Park, Tae‐Sik; Kim, Young Jun; Lee, Jin Hyup; Kim, Jun Ho
• Is Part Of: Molecular nutrition & food research. Volume 62:Issue 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-02-05
• Subjects: apoptosis -- diabetes -- naringin -- oxidative stress -- pancreatic β‐cells; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201700810
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: Oxidative stress has been suggested to play a central role in the pathogenesis of diabetes, as well as other metabolic disorders. Naringin, a major flavanone glycoside in citrus species, has been shown to display strong antioxidant potential in in vitro and in vivo models of oxidative stress; however, the underlying protective mechanisms in diabetes are unclear. Methods and results: To study the protective effects and molecular mechanisms of naringin in preventing islet dysfunction and diabetes, we examined glucose homeostasis, β‐cell apoptosis, and inflammatory response in insulin‐deficient diabetic mice exposed to acute oxidative stress with streptozotocin (STZ). Naringin dose‐dependently ameliorated hyperglycemia and islet dysfunction in insulin‐deficient diabetic mice. Naringin counteracted STZ‐induced β‐cell apoptosis by inhibiting both the intrinsic (mitochondria‐mediated) and extrinsic (death receptor‐mediated) pathways. Furthermore, these protective effects were associated with suppression of DNA damage response and nuclear factor–kappa B– and mitogen–activated protein kinase–mediated signaling pathways, as well as reduction of reactive oxygen species accumulation and pro‐inflammatory cytokine production in the pancreas. Conclusion: Taken together, our study provides insights into the underlying mechanisms through which naringin protects the pancreatic β‐cells against oxidative stress‐induced apoptosis. Abstract : Naringin, a major flavanone glycoside in citrus species, counteracts STZ‐induced islet dysfunction via inhibition of both the intrinsic (mitochondria‐mediated) and extrinsic (death receptor‐mediated) pathways of β‐cell apoptosis, possibly by interfering with DNA damage‐ and cytokine‐induced apoptotic signaling through suppression of pancreatic ROS accumulation and leukocyte infiltration.