Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants. (2nd January 2016)

• Record Type: Journal Article
• Authors: Pelizzo, Gloria; Mimmi, Maria Chiara; Ballico, Maurizio; Marotta, Mario; Goruppi, Ilaria; Peiro, Jose Louis; Zambaiti, Elisa; Costanzo, Federico; Andreatta, Erika; Tonin, Elena; Calcaterra, Valeria
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 29:Number 1(2016)
• Page Start: 143
• Page End: 147
• Publication Date: 2016-01-02
• Subjects: Congenital lung malformations -- metabolomic -- translational research; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2014.991708
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Background : The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy. Methods : Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution 1 H NMR-spectroscopy. Results : Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample. Conclusions : Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.