Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants. (2nd January 2016) - Pelizzo, Gloria
Abstract: Background : The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy. Methods : Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution 1 H NMR-spectroscopy. Results : Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample. Conclusions : Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.