A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes. Issue 5 (3rd June 2018)

• Record Type: Journal Article
• Authors: Ojha, Ruchika; Junk, Peter C.; Deacon, Glen B.; Bond, Alan M.
• Is Part Of: Supramolecular chemistry. Volume 30:Issue 5/6(2018)
• Page Start: 418
• Page End: 424
• Publication Date: 2018-06-03
• Subjects: Intermolecular interactions -- crystal packing -- agostic -- hydrogen bonding -- platinum(II) complexes; Macromolecules -- Periodicals; Supramolecular chemistry -- Periodicals; 547.005
• DOI: 10.1080/10610278.2017.1405003
• Languages: English
• ISSNs: 1061-0278

Abstract

Abstract: A range of supramolecular interactions revealed on assessment of crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{( p -BrC6 F4 )NCH2 CH2 NEt2 }(py)Cl], 1 ; [Pt{( p -HC6 F4 )NCH2 CH2 NEt2 }(py)Cl], 2 ; [Pt{(C6 F5 )NCH2 CH2 NEt2 }(py)I], 3 ; [Pt{( p -HC6 F4 )NCH2 CH2 NMe2 }Cl(py)], 4 ; [Pt{(C6 F5 )NCH2 CH2 NMe2 }Cl0.4 I0.6 (py)], 5 is examined. These interactions frequently include the axial positions above and below the coordination planes. Agostic interactions, inter- and intra-molecular H-bonding and other supramolecular interactions of all compounds were explored for a better understanding of solid state structural properties. This propensity to form a range of supramolecular interactions may assist in docking the drugs to DNA prior to coordination of DNA to these compounds. Abstract : A range of supramolecular interactions are revealed on assessment of the crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{( p -BrC6 F4 )NCH2 CH2 NEt2 }(py)Cl], [Pt{( p -HC6 F4 )NCH2 CH2 NEt2 }(py)Cl], [Pt{(C6 F5 )NCH2 CH2 NEt2 }(py)I], [Pt{( p -HC6 F4 )NCH2 CH2 NMe2 }Cl(py)], [Pt{(C6 F5 )NCH2 CH2 NMe2 }Cl0.4 I0.6 (py)].