A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes. Issue 5 (3rd June 2018) - Ojha, Ruchika
Abstract: A range of supramolecular interactions revealed on assessment of crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{( p -BrC6 F4 )NCH2 CH2 NEt2 }(py)Cl], 1 ; [Pt{( p -HC6 F4 )NCH2 CH2 NEt2 }(py)Cl], 2 ; [Pt{(C6 F5 )NCH2 CH2 NEt2 }(py)I], 3 ; [Pt{( p -HC6 F4 )NCH2 CH2 NMe2 }Cl(py)], 4 ; [Pt{(C6 F5 )NCH2 CH2 NMe2 }Cl0.4 I0.6 (py)], 5 is examined. These interactions frequently include the axial positions above and below the coordination planes. Agostic interactions, inter- and intra-molecular H-bonding and other supramolecular interactions of all compounds were explored for a better understanding of solid state structural properties. This propensity to form a range of supramolecular interactions may assist in docking the drugs to DNA prior to coordination of DNA to these compounds. Abstract : A range of supramolecular interactions are revealed on assessment of the crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{( p -BrC6 F4 )NCH2 CH2 NEt2 }(py)Cl], [Pt{( p -HC6 F4 )NCH2 CH2 NEt2 }(py)Cl], [Pt{(C6 F5 )NCH2 CH2 NEt2 }(py)I], [Pt{( p -HC6 F4 )NCH2 CH2 NMe2 }Cl(py)], [Pt{(C6 F5 )NCH2 CH2 NMe2 }Cl0.4 I0.6 (py)].