I2-catalyzed one-pot synthesis of benzofuro/thieno[2, 3-b]pyrrole motifs. Issue 13 (29th March 2018)

• Record Type: Journal Article
• Authors: Chacko, Priya; Shivashankar, Kalegowda
• Is Part Of: Tetrahedron. Volume 74:Issue 13(2018)
• Page Start: 1520
• Page End: 1526
• Publication Date: 2018-03-29
• Subjects: Iodine -- Benzofuran -- Benzothiophene -- Pyrroles -- Furan -- Thiophene -- Thieno; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2018.02.013
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: A novel I2 -catalyzed one-pot multicomponent protocol for the synthesis of a variety of elusive furo[2, 3- b ]pyrrole and thieno[2, 3- b ]pyrrole libraries has been established. To date, cyclization among alkanone, hydrazine and 2-bromobenzofuran or 2-bromobenzo[ b ]thiophene has not been explored in one-pot. Thus, the proposed single step protocol provides a versatile alternative to existing routes for accessing useful furo[2, 3- b ]pyrrole and thieno[2, 3- b ]pyrrole libraries. Graphical abstract: