Ion chromatography tandem mass spectrometry (IC-MS/MS) multimethod for the determination of highly polar pesticides in plant-derived commodities. (April 2018)

• Record Type: Journal Article
• Authors: Bauer, Anna; Luetjohann, Jens; Rohn, Sascha; Kuballa, Jürgen; Jantzen, Eckard
• Is Part Of: Food control. Volume 86(2018)
• Page Start: 71
• Page End: 76
• Publication Date: 2018-04
• Subjects: Pesticides -- UHPLC-MS/MS -- Ion chromatography -- IC-MS/MS -- Ethephon -- 2-hydroxyethylphosphonic acid -- HEPA -- Chlorate -- Perchlorate; Food -- Quality -- Periodicals; Food -- Analysis -- Periodicals; Food handling -- Periodicals; Food industry and trade -- Quality control -- Periodicals; Aliments -- Industrie et commerce -- Qualité -- Contrôle -- Périodiques; Aliments -- Qualité -- Périodiques; Aliments -- Analyse -- Périodiques; Hygiène alimentaire -- Périodiques; Food -- Analysis; Food handling; Food -- Quality; Periodicals; Electronic journals; 664.07
• DOI: 10.1016/j.foodcont.2017.11.007
• Languages: English
• ISSNs: 0956-7135

Abstract

Abstract: A new sensitive, fast, and robust analytical method based on a QuPPe (Quick Polar Pesticides) extraction procedure coupled to ion chromatography-tandem mass spectrometry (IC-MS/MS) was developed. The study aimed at the determination of the highly polar pesticides chlorate, perchlorate, ethephon, and 2-hydroxyethylphosphonic acid (HEPA) in different plant food commodities. For achieving an acceptable dynamic range for chlorate and perchlorate and to compensate for matrix effects, the isotopically-labelled internal standards 18 O3 -chlorate and 18 O4 -perchlorate and ethephon D4 were applied for calibration. The optimized method was fully validated at levels of 0.010 and 0.100 mg kg −1 for all compounds in the matrices tomato, apple, lemon, sultana, avocado, and wheat according to the actual EU guidance document SANTE/11945/2015. For HEPA and the commodity sultana levels for validation were chosen at 0.050 mg kg −1 and 0.100 mg kg −1 . The precision and accuracy of the validation results were determined at hand of five replicates with recovery rates between 93 and 119% and RSDs between 1 and 14%. The use of internal standards for chlorate, perchlorate and ethephon allows the determination in a wide working range between 0.01 and 1 mg kg −1 without interference by matrix effects. The developed analytical methodology is able to meet the strict requirements for the analysis of baby food. Highlights: IC-MS/MS method for determination of ethephon, HEPA, chlorate, and perchlorate. Quantification at a RL of 0.010 mg/kg in plant-derived commodities. Extension of limited dynamic range of chlorate and perchlorate by ILIS analogues. Method validation in six representative plant-derived commodities.