Erythrocyte polyunsaturated fatty acid levels in young people at ultra-high risk for psychotic disorder and healthy adolescent controls. Issue 1 (30th July 2015)

• Record Type: Journal Article
• Authors: Rice, Simon M.; Schäfer, Miriam R.; Klier, Claudia; Mossaheb, Nilufar; Vijayakumar, Nandita; Amminger, Günter Paul
• Is Part Of: Psychiatry research. Volume 228:Issue 1(2015)
• Page Start: 174
• Page End: 176
• Publication Date: 2015-07-30
• Subjects: Ultra-high risk -- Psychosis -- Polyunsaturated fatty acids; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2015.04.036
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Erythrocyte polyunsaturated fatty acid (PUFA) levels from individuals at ultra-high risk (UHR) for psychosis ( n =80) were compared to existing data from healthy controls ( n =142). Results demonstrated PUFA deficits (α-linolenic acid, eicosapentanoic acid, all ω-6 PUFAs) for the UHR group. Findings provide a rationale for PUFA based interventions in emerging psychosis. highlights: Fatty acids have not been investigated in ultra-high risk (UHR) for psychosis patients. We compared data from 80 antipsychotic naive UHR patients to 142 healthy adolescents. The UHR group had deficits for omega-3 and omega-6 polyunsaturated fatty acids (PUFAs). Findings provide a rationale for PUFA supplementation in UHR cohorts.