Erythrocyte polyunsaturated fatty acid levels in young people at ultra-high risk for psychotic disorder and healthy adolescent controls. Issue 1 (30th July 2015) - Rice, Simon M.
Abstract: Erythrocyte polyunsaturated fatty acid (PUFA) levels from individuals at ultra-high risk (UHR) for psychosis ( n =80) were compared to existing data from healthy controls ( n =142). Results demonstrated PUFA deficits (α-linolenic acid, eicosapentanoic acid, all ω-6 PUFAs) for the UHR group. Findings provide a rationale for PUFA based interventions in emerging psychosis. highlights: Fatty acids have not been investigated in ultra-high risk (UHR) for psychosis patients. We compared data from 80 antipsychotic naive UHR patients to 142 healthy adolescents. The UHR group had deficits for omega-3 and omega-6 polyunsaturated fatty acids (PUFAs). Findings provide a rationale for PUFA supplementation in UHR cohorts.