Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187. (December 2017)

• Record Type: Journal Article
• Authors: Choochuay, Jutatip; Xu, Xin; Rukachaisirikul, Vatcharin; Guedduaythong, Piyada; Phongpaichit, Souwalak; Sakayaroj, Jariya; Chen, Jing; Shen, Xu
• Is Part Of: Phytochemistry letters. Volume 22(2017:Dec.)
• Page Start: 122
• Page End: 127
• Publication Date: 2017-12
• Subjects: Aspergillus polyporicola -- Cytochalasins -- Curvularins -- Soil-derived fungi -- Antimicrobial activity -- Cytotoxic activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.09.011
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new curvularins were isolated from the soil fungus Aspergillus polyporicola PSU-RSPG187. Ten known compounds including five cytochalasins, and five curvularins were also obtained. Known α, β –dehydrocurvularin showed interesting activity against KB and MCF-7 cell lines. Known aspochalasin D was moderately active against flucytosine–resistant Cryptococcus neoformans . This is the first report on chemical constituents of A. polyporicola . Abstract: Two new curvularin derivatives, curvulopyran (1 ) and ent -curvulone A (2 ), along with ten known compounds including five cytochalasins and five curvularins, were isolated from a culture broth of the soil-derived fungus Aspergillus polyporicola PSU-RSPG187. Their structures were determined by spectroscopic methods. Known aspochalasin D displayed moderate antifungal activity against flucytosine–resistant Cryptococcus neoformans with an MIC value of 32 μg/mL and showed no cytotoxic activity against noncancerous cell lines. In addition, known α, β –dehydrocurvularin exhibited potential cytotoxic activity against both KB and MCF-7 cell lines with the IC50 values of 11.26 and 19.50 μM. Unfortunately, it was strongly active against Vero cell lines.