Curvularin derivatives from the soil-derived fungus Aspergillus polyporicola PSU-RSPG187. (December 2017) - Choochuay, Jutatip
Graphical abstract: Highlights: Two new curvularins were isolated from the soil fungus Aspergillus polyporicola PSU-RSPG187. Ten known compounds including five cytochalasins, and five curvularins were also obtained. Known α, β –dehydrocurvularin showed interesting activity against KB and MCF-7 cell lines. Known aspochalasin D was moderately active against flucytosine–resistant Cryptococcus neoformans . This is the first report on chemical constituents of A. polyporicola . Abstract: Two new curvularin derivatives, curvulopyran (1 ) and ent -curvulone A (2 ), along with ten known compounds including five cytochalasins and five curvularins, were isolated from a culture broth of the soil-derived fungus Aspergillus polyporicola PSU-RSPG187. Their structures were determined by spectroscopic methods. Known aspochalasin D displayed moderate antifungal activity against flucytosine–resistant Cryptococcus neoformans with an MIC value of 32 μg/mL and showed no cytotoxic activity against noncancerous cell lines. In addition, known α, β –dehydrocurvularin exhibited potential cytotoxic activity against both KB and MCF-7 cell lines with the IC50 values of 11.26 and 19.50 μM. Unfortunately, it was strongly active against Vero cell lines.