Efficient dehydrative alkylation of thiols with alcohols catalyzed by alkyl halides. Issue 45 (8th November 2017)

• Record Type: Journal Article
• Authors: Yang, Yaqi; Ye, Zihang; Zhang, Xu; Zhou, Yipeng; Ma, Xiantao; Cao, Hongen; Li, Huan; Yu, Lei; Xu, Qing
• Is Part Of: Organic & biomolecular chemistry. Volume 15:Issue 45(2017)
• Page Start: 9638
• Page End: 9642
• Publication Date: 2017-11-08
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02461d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Alcohols can be efficiently converted into thioethers by a transition metal- and base-free alkyl halide-catalyzed S -alkylation reaction with thiols or disulfides. Abstract : Alcohols can be efficiently converted into the useful thioethers by a transition metal- and base-free dehydrative S -alkylation reaction with thiols or disulfides by employing alkyl halides as the effective catalyst. This simple and efficient method is a green and practical way for the preparation of thioethers, as it tolerates a wide range of substrates such as aryl and alkyl thiols, as well as benzylic, allylic, secondary, tertiary, and even the less reactive aliphatic alcohols.