Efficient dehydrative alkylation of thiols with alcohols catalyzed by alkyl halides. Issue 45 (8th November 2017) - Yang, Yaqi
Abstract : Alcohols can be efficiently converted into thioethers by a transition metal- and base-free alkyl halide-catalyzed S -alkylation reaction with thiols or disulfides. Abstract : Alcohols can be efficiently converted into the useful thioethers by a transition metal- and base-free dehydrative S -alkylation reaction with thiols or disulfides by employing alkyl halides as the effective catalyst. This simple and efficient method is a green and practical way for the preparation of thioethers, as it tolerates a wide range of substrates such as aryl and alkyl thiols, as well as benzylic, allylic, secondary, tertiary, and even the less reactive aliphatic alcohols.