Identification of cis/trans isomers of menaquinone-7 in food as exemplified by dietary supplements. (15th March 2018)

• Record Type: Journal Article
• Authors: Szterk, Arkadiusz; Zmysłowski, Adam; Bus, Katarzyna
• Is Part Of: Food chemistry. Volume 243(2018)
• Page Start: 403
• Page End: 409
• Publication Date: 2018-03-15
• Subjects: Menaquinone-7 -- Vitamin K2MK-7 -- Impurities of dietary supplements -- Cis/trans isomers; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2017.10.001
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: New method of marking the six different isomers of vitamin K2 MK-7. 5 different isomers of cis / trans vitamin K2 MK-7 were identified and detected. Cis / trans isomers exceeded the content of all trans K2 MK-7 form even 3.7 times. Abstract: For the first time, the cis / trans isomer content of menaquinone-7 in food products has been identified and marked. A novel method of marking isomers of vitamin K2 MK-7 in dietary supplements was developed and validated. Five different isomers of cis / trans vitamin K2 MK-7 were identified. Identification of cis / trans isomers was performed by HRMS-QTOF, whereas their quantities were determined by using CAD and DAD detectors. In the majority of cases, the content of biologically active all trans vitamin K2 MK-7 was below its declared content. The content of all trans K2 MK-7 was in the range between 5.5 and 49 µg in pills. In one of the studied supplements, this vitamin was not found, regardless of the claim on the product label. The content of cis / trans isomers in certain dietary supplements exceeded the content of all trans K2 MK-7 by up to 3.7 times.