Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. Issue 11 (2nd November 2017)

• Record Type: Journal Article
• Authors: Wang, Hui-Qiang; Hu, Jin; Yan, Hai-Yan; Wu, Shuo; Li, Yu-Huan
• Is Part Of: Journal of Asian natural products research. Volume 19:Issue 11(2017)
• Page Start: 1124
• Page End: 1133
• Publication Date: 2017-11-02
• Subjects: Corydaline -- enterovirus 71 -- MAPK -- COX-2; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1386658
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro . Based on these findings, corydaline could be a potential lead or supplement for the development of new anti-EV71 agents in the future. Abstract :