Corydaline inhibits enterovirus 71 replication by regulating COX-2 expression. Issue 11 (2nd November 2017) - Wang, Hui-Qiang
Abstract: Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro . Based on these findings, corydaline could be a potential lead or supplement for the development of new anti-EV71 agents in the future. Abstract :