Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy. (February 2015)

• Record Type: Journal Article
• Authors: Zhang, Hao; Wu, Huixia; Wang, Jun; Yang, Yan; Wu, Dongmei; Zhang, Yingjian; Zhang, Yang; Zhou, Zhiguo; Yang, Shiping
• Is Part Of: Biomaterials. Volume 42(2015)
• Page Start: 66
• Page End: 77
• Publication Date: 2015-02
• Subjects: Graphene oxide -- BaGdF5 -- X-ray computed tomography imaging -- Magnetic resonance imaging -- Photothermal therapy; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2014.11.055
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: By using a solvothermal method in the presence of polyethylene glycol (PEG), BaGdF5 nanoparticles are firmly attached on the surface of graphene oxide (GO) nanosheets to form the GO/BaGdF5 /PEG nanocomposites. The resulting GO/BaGdF5 /PEG shows low cytotoxicity, positive magnetic resonance (MR) contrast effect and better X-ray attenuation property than Iohexol, which enables effective dual-modality MR and X-ray computed tomography (CT) imaging of the tumor model in vivo . The enhanced near-infrared absorbance, good photothermal stability and efficient tumor passive targeting of GO/BaGdF5 /PEG result in the highly efficient photothermal ablation of tumor in vivo after intravenous injection of GO/BaGdF5 /PEG and the following 808-nm laser irradiation (0.5 W/cm 2 ). The histological and biochemical analysis data reveal no perceptible toxicity of GO/BaGdF5 /PEG in mice after treatment. These results indicate potential application of GO/BaGdF5 /PEG in dual-modality MR/CT imaging and photothermal therapy of cancers.