Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy. (February 2015) - Zhang, Hao
Abstract: By using a solvothermal method in the presence of polyethylene glycol (PEG), BaGdF5 nanoparticles are firmly attached on the surface of graphene oxide (GO) nanosheets to form the GO/BaGdF5 /PEG nanocomposites. The resulting GO/BaGdF5 /PEG shows low cytotoxicity, positive magnetic resonance (MR) contrast effect and better X-ray attenuation property than Iohexol, which enables effective dual-modality MR and X-ray computed tomography (CT) imaging of the tumor model in vivo . The enhanced near-infrared absorbance, good photothermal stability and efficient tumor passive targeting of GO/BaGdF5 /PEG result in the highly efficient photothermal ablation of tumor in vivo after intravenous injection of GO/BaGdF5 /PEG and the following 808-nm laser irradiation (0.5 W/cm 2 ). The histological and biochemical analysis data reveal no perceptible toxicity of GO/BaGdF5 /PEG in mice after treatment. These results indicate potential application of GO/BaGdF5 /PEG in dual-modality MR/CT imaging and photothermal therapy of cancers.