One‐Pot Synthesis of 2‐Amino‐1, 3‐selenazole via an Intermediary Amidinoselenourea. Issue 15 (17th April 2015)

• Record Type: Journal Article
• Authors: Ranjan, Alok; Yerande, Ragini; Jadhav, Mahantesh; Yerande, Swapnil G.; Dethe, Dattatraya H.
• Is Part Of: European journal of organic chemistry. Issue 15(2015)
• Page Start: 3230
• Page End: 3234
• Publication Date: 2015-04-17
• Subjects: Synthetic methods -- Amidino­selenoureas -- 2‐Amino‐1, 3‐selenazoles -- Isoselenocyanates -- Multicomponent reactions; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.201500168
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: Herein we describe a sequential one‐pot multicomponent reaction for the synthesis of 2‐amino‐1, 3‐selenazole. Amidinoselenourea synthesized from isoselenocyanate and N, N ‐diethyl‐amidine reacted with various halomethylene compounds to furnish 2‐amino‐1, 3‐selenazole derivatives in 65–89 % yields. The molecular structure of the trisubstituted selenazole formed was unambiguously established by X‐ray crystallography. Abstract : An efficient method for the synthesis of 2‐amino‐1, 3‐selenazole by a sequential one‐pot multicomponent reaction between isoselenocyanate and N, N ‐diethyl‐amidine has been developed. It represents a step‐economical way to construct a range of 2‐amino‐1, 3‐selenazole derivatives in 65–89 % yields. The structure of the trisubstituted selenazole formed was unambiguously established by X‐ray crystallography.