One‐Pot Synthesis of 2‐Amino‐1, 3‐selenazole via an Intermediary Amidinoselenourea. Issue 15 (17th April 2015) - Ranjan, Alok
Abstract: Herein we describe a sequential one‐pot multicomponent reaction for the synthesis of 2‐amino‐1, 3‐selenazole. Amidinoselenourea synthesized from isoselenocyanate and N, N ‐diethyl‐amidine reacted with various halomethylene compounds to furnish 2‐amino‐1, 3‐selenazole derivatives in 65–89 % yields. The molecular structure of the trisubstituted selenazole formed was unambiguously established by X‐ray crystallography. Abstract : An efficient method for the synthesis of 2‐amino‐1, 3‐selenazole by a sequential one‐pot multicomponent reaction between isoselenocyanate and N, N ‐diethyl‐amidine has been developed. It represents a step‐economical way to construct a range of 2‐amino‐1, 3‐selenazole derivatives in 65–89 % yields. The structure of the trisubstituted selenazole formed was unambiguously established by X‐ray crystallography.