Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?. (3rd September 2017)
- Record Type:
- Journal Article
- Title:
- Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?. (3rd September 2017)
- Main Title:
- Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?
- Authors:
- Chin, Venessa T.
Vennin, Claire
Timpson, Paul
Pajic, Marina - Abstract:
- ABSTRACT: Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased in vivo primary tumor growth, metastasis and improved response to standard-of-care therapy in pancreatic cancer. Automated analysis of collagen organization in patient tumors may present a promising tool to predict response to our proposed treatment.
- Is Part Of:
- Molecular & cellular oncology. Volume 4:Number 5(2017)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 4:Number 5(2017)
- Issue Display:
- Volume 4, Issue 5 (2017)
- Year:
- 2017
- Volume:
- 4
- Issue:
- 5
- Issue Sort Value:
- 2017-0004-0005-0000
- Page Start:
- Page End:
- Publication Date:
- 2017-09-03
- Subjects:
- Extracellular matrix -- pancreatic cancer -- Rho GTPase -- ROCK inhibitors -- tailored therapy
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2017.1333973 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 4816.xml