Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?. (3rd September 2017) - Chin, Venessa T.
ABSTRACT: Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased in vivo primary tumor growth, metastasis and improved response to standard-of-care therapy in pancreatic cancer. Automated analysis of collagen organization in patient tumors may present a promising tool to predict response to our proposed treatment.