Hypolipidaemic and antioxidant capacities of polysaccharides obtained from Laminaria japonica by different extraction media in diet‐induced mouse model. (15th June 2017)

• Record Type: Journal Article
• Authors: Yao, Yujing; Xiang, Huan; You, Lijun; Cui, Chun; Sun‐Waterhouse, Dongxiao; Zhao, Mouming
• Is Part Of: International journal of food science & technology. Volume 52:Number 10(2017)
• Page Start: 2274
• Page End: 2281
• Publication Date: 2017-06-15
• Subjects: Antioxidants -- citric acid -- hypolipidaemic -- Laminaria japonica -- polysaccharides; Food industry and trade -- Periodicals; 664
• DOI: 10.1111/ijfs.13508
• Languages: English
• ISSNs: 0950-5423

Abstract

Summary: This study shows the industrial feasibility of using aqueous methods to produce antioxidative and hypolipidaemic polysaccharides from Laminaria japonica (LJP). Comparison was firstly made among the polysaccharides prepared using different extraction media, that is water alone (LJPW) and citric acid (LJPC), sulphuric acid, hydrochloric acid and phosphoric acid. LJPC enabled the highest extract yield (~11% dry weight), bile salt adsorption rate (~59% dry weight), ABTS radical scavenging activity (IC50 value 1.06 mg mL −1 ) and ORAC antioxidant activity (341.87 μmol Trolox g −1 ). In animal trial using diet‐induced high‐fat mice, oral administration of LJP produced with citric acid (LJPC) at a high dose (200 mg kg −1 body mass per day) enabled significantly higher serum HDL‐C, lower LDL‐C/HDL‐C and unaltered LDL‐C, whilst a medium dose (100 mg kg −1 body mass per day) significantly decreased LDL‐C. Administration of LJP produced with water (200 mg kg −1 body mass per day) significantly lowered serum LDL‐C. Therefore, LJP may provide dose‐dependent pharmacological and therapeutic effects to combat atherosclerosis through their hyperlipidaemic and antioxidant properties. Abstract : This manuscript revals that the aqueous extraction methods with and without citric acid could produce such hyperlipidaemic and antioxidative polysaccharides from L. japonica .